Liraglutide (Saxenda) for Weight Loss: In its clinical trials (the SCALE trials), patients taking Saxenda alongside lifestyle changes lost an average of 5% to 8% of their initial body weight over 56 weeks
One randomized controlled trial demonstrated that choline supplementation (750 mg/day of choline in the form of phosphatidylcholine administered from week 18 of gestation through 90 days postpartum) in pregnant women consuming a moderate-choline diet (approximately 360 mg/day) was safe but did not enhance infant cognitive function at 10 or 12 months of age (215)
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Liraglutide improved cognition in an open-label study of mood disorders, but exenatide failed to do the same in a small RCT of schizophrenia with obesity
It releases inflammatory signals and hormones that can lead to insulin resistance, higher cortisol, and a sluggish metabolic rate
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